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Augtyro can now be used in patients aged 12 years and older whose disease has progressed after initial treatment as well as patients with no satisfactory alternative therapies and those who are likely to suffer from severe morbidity due to surgical resection, according to BMS

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Antioxidant mechanisms are regulatory systems that inhibit ferroptosis System Xc /GSH/GPX4 axis: The system Xc is an input cystine/output glutamate reverse transport system, which includes two subunits, SLC3A2 and SLC7A11 (Koppula et al., 2021b)

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The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses

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In intestinal tissues, IR decreases GSH levels and inhibits GPX4 expression, thereby promoting ferroptosis [39]

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