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Possible explanations include: Placebo effect : Expecting increased energy may influence perceived alertness Correction of deficiency : People with B12 deficiency often experience fatigue and disrupted sleep patterns

[5] [6] Individuals taking certain medications may also need higher doses, including those on metformin (commonly prescribed for type 2 diabetes), proton pump inhibitors, or H2-receptor antagonists for extended periods

Physico-chemical properties 4.3.1

Injections have their place for potency and rapid effects, but nasal sprays are significantly more convenient and affordable, making them a fast-growing alternative