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Additionally, the acute induction of GzmB contributes to fulminant hepatitis, a rapidly developing and lethal syndrome (143)

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It readily crosses the blood-brain barrier, influencing neurotransmitter synthesis and release, enhancing synaptic function, and promoting nerve cell regeneration

Rich lipofuscin granules have been observed in lymphocytes from aged mice, and it is known that lipofuscin may act as a danger signal, stimulating the release of pro-inflammatory chemokines and cytokines and activating macrophages, thereby leading to a chronic oxidative-inflammatory process 52