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In the same way, the MTHFR gene works with riboflavin and other upstream folates to produce methylfolate

Oxid Med Cell Longev 2021(1):6635460 Mathur A, Pandey VK, Kakkar P (2018) Activation of GSK3/-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy