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Research shows that mycotoxins reduce beneficial bacteria such as Lactobacillus and Bifidobacterium, while promoting the overgrowth of inflammatory species, particularly from the Proteobacteria phylum

10.1089/neu.1996.13.223 J

4-Octyl itaconate alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the KEAP1-NRF2 pathway

In patients that met the NIT criteria, the following reasons were exclusionary from treatment with resmetirom based on the histological findings: 34 (9.3%) had cirrhosis on biopsy (F4), 117 (32.0%) had F0-F1, and 70 (19.1%) had F2-F3 but NAS 30% was defined as unreliable