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Lamellipodia are modulated by RhoA and other Rho-GTPases, impacting actin polymerization, and the authors showed inhibition of RhoA activity by IIAMD

78 However, the demonstration of endothelial dysfunction in the presence of increased expression of eNOS indicates that the capacity of the enzyme to produce NO may be limited, and the concept that eNOS itself can be a superoxide source and thereby contributes to endothelial dysfunction provides a further explanation to this observation

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Further Reading: Calcium AKG Anti-Ageing Benefits End Note Glutathione is a powerful antioxidant needed for maintaining health and fighting oxidative stress