nac and glutathione recent publications Frontiers The mechanism of action of

In a sensitized system especially with mast cell instability or a history of Mast Cell Activation Syndrome these same pathways can shift: Increased histamine release Neurogenic inflammation Vascular reactivity Delayed hypersensitivity-type responses What was meant to heal can present as: flushing, burning, swelling, or persistent erythema

doi: 10.1038/srep19213 105 DhillonVSDeoPFenechM

Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ

The excellent Higuchi correlation (R=0.97) also indicates the importance of diffusion as one of the main mechanisms contributing to the release rate