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BPC-157 has not received approval due to the absence of sufficient clinical studies confirming its health benefits in humans, according to the Food and Drug Administration (FDA)

The potency of oral medications diminishes as they travel through the digestive tract, and absorption is further slowed by the transit time through the stomach and intestines prior to entering the bloodstream

The symptoms and signs of acromegaly (e.g., arthropathy, carpal tunnel syndrome, generalized visceromegaly, macroglossia, hypertension, glucose intolerance, headache, lethargy, excess perspiration, and sleep apnea) progress slowly, and diagnosis often is delayed

doi: 10.1016/0024-3205(92)90504-I