The pattern is clean and worth stating plainly: the yes votes were the eight members seated in June, and the no votes came predominantly from the academic and clinical members
Medical Imaging Drugs Advisory Committee Meeting
furano[5',4':3,4]-9-hydroxy-10-prenylpterocarpan, a pterocarpan isolated from stem bark of Erythrina lysistemon, inhibits PTPB1 erysubin D - - eryvarin D - - ethyl (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-6,6,10a,12a-tetramethyl-1,2,3,3a,3b,4,6,6a,7,9a,10,10a,10b,11,12,12a-hexadecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]pentanoate - - ethyl (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-8-amino-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-1-yl]pentanoate - - ethyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-(4-chlorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-(4-fluorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-(4-methoxyphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-(4-methylphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-(4-nitrophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-4-[(E)-2-phenylethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl (4R)-6-(propan-2-yl)-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate - ethyl 2-(2-((5-(naphthalen-2-yloxy)-1H-benzimidazol-2-yl)thio)acetamido)thiazole-4-carboxylate - ethyl 2-(2-bromophenyl)-4-[(4-methoxyphenoxy)methyl]-1,3-thiazole-5-carboxylate reaction mode analysis by molecular docking and molecular dynamics simulation ethyl 2-(2-bromophenyl)-4-[(4-methylphenoxy)methyl]-1,3-thiazole-5-carboxylate - ethyl 2-(2-bromophenyl)-4-[(4-nitrophenoxy)methyl]-1,3-thiazole-5-carboxylate - ethyl 2-(4-bromophenyl)-4-[(4-methoxyphenoxy)methyl]-1,3-thiazole-5-carboxylate - ethyl 2-(4-bromophenyl)-4-[(4-nitrophenoxy)methyl]-1,3-thiazole-5-carboxylate - ethyl 2-(4-fluorophenyl)-4-[(4-methylphenoxy)methyl]-1,3-thiazole-5-carboxylate - ethyl 4-(2-((5-(naphthalen-1-yloxy)-1H-benzimidazol-2-yl)thio)acetamido)benzoate - ethyl 4-(2-((5-(naphthalen-2-yloxy)-1H-benzimidazol-2-yl)thio)acetamido)benzoate - ethyl 4-[(4-chlorophenoxy)methyl]-2-(3-phenoxyphenyl)-1,3-thiazole-5-carboxylate - ethyl 4-[(4-methoxyphenoxy)methyl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxylate - ethyl 4-[(4-methylphenoxy)methyl]-2-(3-nitrophenyl)-1,3-thiazole-5-carboxylate - ethyl 4-[(4-methylphenoxy)methyl]-2-(3-phenoxyphenyl)-1,3-thiazole-5-carboxylate - ethyl 4-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]butanoate - - ethyl [4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]acetate - - ethyl-3,4-dephostatin - FlAsH the small molecule biarsenical fluorescein derivative, FlAsH, is no inhibitor of the wild-type enzyme but of the engineered WPD insertion mutant enzyme that displays FlAsH-binding cysteine residues
10.2147/cia.s158513 78 LiuZ.ChenX.LiZ.YeW.DingH.LiP.et al (2020)
