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The ECM not only determines tissue structure but also regulates many cellular processes through determining the bio-availability of cytokines, chemokines and growth factors, 85,86,87 and by directly influencing the migration and activation of cells 83,88 hence influencing immune responses

[Updated 2021 Feb 9]

It is possible that some people who develop symptoms of a vitamin B12 deficiency with no clear causative factors may have antibody-negative pernicious anaemia[2]