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These were further chelated by Mn ions for serving as a magnetic resonance imaging (MRI) contrast agent and PEGylated (HMONs-MnPpIX-PEG) [66]

The activity and expression of NRF2 were decreased in many AKI and CKD animal models, suggesting that NRF2 was an important mediator in the pathogenesis and progression of AKI and CKD [204, 205]

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This provides a mechanistic basis for portal pressure reduction in the context of IGF-1 deficiency-associated portal hypertension in cirrhosis, studied using mesenteric venous pressure catheters and microsphere-based portal blood flow quantification