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The shared pathological mechanisms discussed below are graphically summarized in Figure 1, and the corresponding molecular targets and druggable nodes are illustrated in Figure 2

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These findings align with clinical evidence showing that SIRT1 activators can alleviate fatty liver in MASLD patients, highlighting its pivotal role in lipid-related disease through the AMPK pathway 39,40

Zhou J, Yang Y, Xie Z, Lu D, Huang J, Lan L et al (2024) Dysbiosis of gut microbiota and metabolites during AIDS: implications for CD4 + T cell reduction and immune activation