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Other side effects Additional reported side effects include: Joint pain and water retention Muscle and joint aches Headaches and nausea Receptor desensitization with prolonged use Potential suppression of natural GH and IGF-1 production Who should avoid IGF-1 LR3 Certain groups should not use IGF-1 LR3: Anyone with active cancer or tumor history Those with severe insulin resistance or diabetes Pregnant or nursing women Anyone under 25 whose growth plates haven't closed Those with existing hormonal imbalances IGF-1 LR3 is not FDA-approved for general medical use and remains primarily a research compound

Timeframe and commitment While semaglutide and lipotropic injections can help you achieve your weight loss goals, it can take time and commitment to other lifestyle interventions to see any results

What I can say is that it worked for me when nothing else did

Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents (Toxicology and Applied Pharmacology)