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The canonical pyroptosis pathway is initiated by the activation of the NLRP3 inflammasome complex, which includes NLRP3, the adaptor protein ASC containing the CARD domain, and pro-caspase-1 [65]

To control for multiple comparisons in multiplex assays, brain region MRI analysis and correlation analysis, FDR was applied using the BenjaminiHochberg correction

A large number of neuroprotective agents have been found in animal and cell brain injury models, and none of them have shown positive long-term results in clinical trials (Menon, 2009

TCC-treated wounds also had significantly lower concentrations of TNF-alpha and MMP-2 and MMP-9, indicating reduced inflammation and enhanced healing