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Dynamic light scattering (DLS) measurement The mean particle size and PDI of the prepared nanodispersions (diluted by a factor of 10) were determined using DLS with a particle sizing system (Zetasizer Nano ZS, Malvern, UK) at 25 C

(4) Ischemia reperfusion (I/R) injury The term I/R injury refers to the process of saving the ischemic heart muscle by restoring cardiac function without improvement or deterioration through early blood flow following procedures such as coronary angioplasty, percutaneous coronary intervention therapy, and coronary artery bypass grafting (CABG) [140]

Age, sex, cohort, and HIV-1 subtype were assessed a priori as potential confounders for all subsequent analyses based on existing literature and biological relevance