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This hypothesis was confirmed in a recent study that the inflammation inhibitor IL-37 boosted MSU phagocytosis by macrophages, lowered the transcription of pyroptosis-associated proteins, and diminished the release of inflammatory cytokines post-phagocytosis, thereby mitigating the inflammatory response in gout (54)

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Thus, it may be concluded that this cellular subtype shows, a behavior more comparable to the actual in vivo situation regarding its response to CTX

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