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C.Fletcher-SananikoneE.et al (2012)

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Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia

however, available evidence from repeated-dose animal studies and clinical observations suggests a favorable safety margin, with no evidence of dependence, tolerance, or withdrawal phenomena (6)