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Oral analgesics, including acetaminophen and opioids, and intra-articular injections, such as corticosteroids and hyaluronic acid, provide varying degrees of relief but are limited by potential side effects

Opioids Due to their relatively high incidence of side effects, including drowsiness, dizziness, and nausea, as well as the potential for harm with long-term use, opioids are typically prescribed for osteoarthritis (OA) only when other analgesics have proven ineffective or are contraindicated (70)

(2007) Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation