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Additionally, the activation of melatonin MT1 receptors can suppress ferroptosis through the sirtuin 1/NRF2/heme oxygenase 1 (HO-1)/GPX4 signaling cascade (58)

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However, hyperactivation of the Nrf2 pathway creates an environment that favors the survival of normal as well as malignant cells, protecting them against oxidative stress, chemotherapeutic agents, and radiotherapy imparting it an oncogenic property, and Nrf2 can be a powerful putative therapeutic target in cancer treatment (Figure 3B)

This result was in agreement with (Xu et al., 2023), who previously demonstrated the ability of PA to alleviate structural liver damage in CCL4-induced hepatoxicity in mice