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Schweigreiter, R

Preventing HGF nitration-dysfunction could also improve the therapeutic effects of investigational HGF drugs for various diseases including liver cirrhosis, chronic renal failure, lung fibrosis, myocardial infarction, arteriosclerosis obliterans, amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease), and acute spinal cord injury 47,48,49,50,51,52,53,54,55

These conditions promote NLRP3 inflammasome assembly, triggering caspase-1 activation and subsequent plasma membrane permeabilization (85)

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