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the subject may be a child

In certain embodiments, such modulation toward a pro-inflammatory state may be measured in a variety of well-known ways, including but not limited to one or more of the following: a) increased cluster of differentiation 80(CD80), CD86, MHCII, MHCI, interleukin 1-beta (IL-1 beta), IL-6, CCL3, CCL4, CXCL10, CXCL9, GM-CSF and/or tumor necrosis factor alpha (TNF-alpha)

by polynucleotide reassembly &/or polynucleotide site-saturation mutagenesis) and screened for binding to immobilized EL-5R for the initial screening

It is acknowledged that this may elevate the Type I error rate, although the tests were confined to planned comparisons between specific groups