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Uric Acid Production as a Target of Therapy in Patients With Gout In the catabolism of purines, uric acid generation by the enzyme xanthine oxidase (that also has xanthine dehydrogenase activity) ( Figure 1 - 2 ) highlights the key therapeutic mechanisms of action of the xanthine oxidase inhibitors allopurinol and febuxostat ( Pharmacologic Urate-Lowering Therapy )

Glutathione, initially described as philothion or love of sulfur was crystallized, determined to contain sulfur and renamed glutathione (125)

Lucey MR, Brown KA, Everson GT, Fung JJ, Gish R, Keefe EB, et al

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