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GFR 30-49 ml/min: 250-750 mg q12hr

Recent experimental studies have suggested that moderately elevated homocysteine levels are a causal risk factor for atherothrombotic disease because they affect both the vascular wall structure and the blood coagulation system

Many experts believe that MTHFR testing should only be used in specific scenarios, as the clinical implications of these mutations are still not fully understood in many cases.

Early observational data suggests that patients on GLP-1 therapy for weight loss may see B12 levels decline by 10-15% over six to twelve months, depending on baseline status and dietary intake