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The underlying mechanism through which the circadian rhythm regulates testosterone secretion may involve the activation of the PKAsteroid acute regulatory protein signaling pathway [71]

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These include reduced gonadotropin secretion due to impaired positive estrogen feedback on luteinizing hormone (LH) secretion in women (21), increased adrenal androgen secretion (22), and direct blockade of gonadotropin action at the gonadal level (23, 24)