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We found that aggressive TNBC cells are characterized by higher expression of FADS1/2, leading to enhanced PUFA availability and thus becoming more sensitive to ferroptosis-promoting insults, a finding validated both in vitro and in vivo

While no antagonistic interactions were observed, this screening approach identified synergistic effects between loss of ABCC1 or ABCA2 and Venetoclax treatment (Fig

Neurotrophic factors, essential proteins that support the growth, survival, and differentiation of neurons, are vital for maintaining neuronal health and function

Vader P, Mol EA, Pasterkamp G, Schiffelers RM (2016) Extracellular vesicles for drug delivery