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These substances can not only attack the cell membrane and organelles, but can also destroy proteins, membrane phospholipids and nucleic acids, resulting in cell death or apoptosis

This suggests that contacts outside of the ligand-binding site contribute to its improved affinity in the presence of ENL and, indeed, our model revealed an extensive interfacial interaction between CRBN and ENL YEATS, with a buried solvent-accessible surface area of ~2,258 2 and a high degree of shape complementarity (0.64 out of 1) 52

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