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Immunity 44, 380390, doi: 10.1016/j.immuni.2016.01.021 (2016)

In one study, the cells depleted of mitochondria could still undergo ferroptosis [14], while in another study authors described significantly attenuated ferroptosis [3]

The peripheral IGF-1/IGF-1R pathway may play a role in promoting pain, while the central (spinal cord) IGF-1/IGF-1R pathway may play a role in inhibiting pain