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However, the presence of waterinsoluble excipients in the formulation makes i.v

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320 GouLZhaoLSongWWangLLiuJZhangHet al

Increased oxidative stress can disrupt the formation of disulfide bonds within the ER, leading to ER stress

many of the new proteins have been identified by positional cloning of the genes harbouring the disease-causing mutations New diagnostic assays for B 12 deficiency are being developed