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The sustained lipid peroxidation chain reaction results in progressive loss of membrane fatty acids, with consequent decrease in membrane fluidity, increased non-specific permeability to ions, and inhibition of membrane bound receptors and enzymes ( Besides their role in mediating lipid peroxidation, ROS especially nitric oxide (NO ), and OH (92), have also been shown to attach to sperm DNA molecules causing excessive modifications and deletions in their nucleotide bases and strand breakages, along with other multiple genotoxic effects (93)

The physical inactivity induces protein ubiquitination and autophagy biomarkers [120]