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J Exp Clin Cancer Res 39 , 228 (2020)

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This, in turn, results in the upregulation of PD-L1 in bladder cancer cells, the activation of the EGFR/ERK/C-Jun signaling pathway, and the facilitation of tumor immune escape [103, 104]

Bibcode:2012CSRev..41.1499F

It is suggested that blood glucose and insulin levels should be monitored during its administration due to the risk of progression to glucose intolerance or the development of T2D, especially in genetically predisposed individuals ( 2.6 Role of growth hormone in the aging brain The role of HGH extends beyond body growth and metabolism, affecting several neuroendocrine and cognitive functions