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MOTS-C: Limited safety data exists from human studies

+ B12 injections suit vegetarians and vegans who do not eat animal foods, patients with confirmed absorption issues such as pernicious anaemia, coeliac disease or significant IBS, older adults whose stomach acid has dropped with age, and patients on long-term metformin or proton-pump inhibitors that lower B12 absorption

Briefly, standard culture media was supplemented with scheduled addition of adipogenic agents [3-isobutyl-1methyl xanthine (IBMX), Sigma Aldrich

Caveat, applied to both : on the specific question of proven human fat-loss therapy, both compounds score identically: not demonstrated