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In a slice model of hippocampal ischemia, Andrade and Rossi ( 2+ entry and release from intracellular stores, actin filament depolymerization, and vesicular release of glutamate, which is dependent on actin dynamics but independent of [Ca 2+ ] i rise

Direct and prolonged contact of copper with skin may result in electrochemical reactions to release copper ions, which are diffusible through the skin 2

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Nevertheless, the molecular mechanisms underlying these risk factors are poorly understood