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Melasma is a skin condition characterized by the appearance of dark patches on certain areas of the face such as the forehead, upper lip, bridge of nose and upper cheeks

When Burnet first learnt of the technique he declared it would become 'the most powerful weapon in antibody formation studies.' Other immunologists were equally impressed by the simplicity of the method with Edwin Lennox describing it as 'experimental brilliance and analytical thinking in the finest combination' (Marks)

Diarrhea is another commonly reported gastrointestinal side effect that may range from mild loose stools to more significant episodes that could lead to fluid and electrolyte imbalances if severe or prolonged

The finer gauge causes less discomfort