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It is imperative to exclude other causes of fatigue such as iron deficiency and thyroid dysfunction before addressing the drivers of HPA axis dysfunction

Inflammation of IVD may be characterized by elevated expression of proinflammatory molecules such as interleukins (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, and IL-17), TNF-, IFN-, chemokines and prostaglandin E2 (PGE2), leading to the development of IDD and LBP (Molinos et al., 2015

At turns devastating and ecstatic and wildly illuminating, 'The Wake' reveals an artist highly attuned to the task of preserving the human spirit in an often-unforgiving world

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