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This again is a major oversimplification, as the theory (and the use of HRV as a general proxy) assumes namely that consistent patterns in the activity of different vegetative efferents (towards the heart, lung, gut etc) should be observed, but this prediction is frequently not verified (319)

This severe metabolic blockade reduces the transmitter content of individual vesicles by more than 50%, resulting in a dramatic decrease in quantal size and a rapid, dose-independent decay of the sympathomimetic response (Sulzer et al, 1995

(8) Pharmacological identity with other chemical substances

Activation of STING via cGAS-mediated recognition of double-stranded DNA results in phosphorylation and nuclear localization of IRF3, culminating in the production of type I interferons (IFN) and induction of local immune responses 17