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As different environmental conditions and chemical compounds can lead to ER stress, it is however difficult to pinpoint at how ITC might trigger ER stress

For both the eddy-permitting 1/4 and eddy-resolving 1/12 model configurations, three DA experiments are conducted and compared with a free model integration (denoted as FREE): 1) assimilating only the in situ temperature and salinity profile measurements from WOD18 (denoted as PROF) 2) simultaneously assimilating both the in situ temperature and salinity profile observations as well as the surface drifter GPS locations (denoted as BOTH), and 3) simultaneously assimilating both of the temperature and salinity profiles as well as the derived drifter proxy Eulerian velocities (denoted as BOTHvel)

These findings suggest that cell replacement therapy may be beneficial if appropriate patients are selected