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The combination of BSO+L-PAM achieved synergistic cytotoxicity (combination index number (CIN) 0.7) and induced 24 logs of cell kill in all nine MM cell lines including the eight lines established at progressive disease (PD) after therapy (U266, OPM-2, NCI H929, KMS-12-PE, EJM, TX-MM-030h, MM.1S and MOLP-2), 25 which include lines with cytogenetic profiles associated with a poor prognosis (Figure 1b)

Description: Thyrotropin Releasing Hormone Human Thyroliberin, TRH, MGC125964, MGC125965, Protirelin, TRF

The first-eluting diastereomer was designated as Example 23, and the second-eluting diastereomer as Example 24

The N -methyl-D-aspartate (NMDA) receptor is the main receptor of glutamate, which is the primary excitatory neurotransmitter in the brain