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The differential diagnosis may include: (1) idiopathic developmental delay or mental retardation (cognitive impairment) (2) cerebral palsy (3) gastroesophageal reflux (4) food allergy (5) growth failure due to liver, renal, or endocrine disease (6) Reye syndrome (7) other defects in the metabolism of ammonia, amino acids, organic acids, and fatty acids Diagnosing the specific type of methylmalonic acidemia requires measuring enzyme activity, usually via the indirect assessment of radiolabeled propionate incorporation into protein in cultured skin fibroblasts or identifying an abnormal disease-causing gene mutation

The supernatant was sterilized by filtration through 0.22-m filters

Kreis R

Improves insulin sensitivity for better glucose metabolism