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The pathological features of PD, particularly iron accumulation, oxidative stress, and mitochondrial dysfunction, bear striking similarities to the hallmarks of ferroptosis

Fungus is a major cause because it does the following: Damages the nail bed and nail attachment Causes inflammation that interferes with the connection Damages or irritates the nail bed from its waste products Damages the tissue from the infection Causes issues from the increased keratin production Let us point out that any severe damage or disease can lead to toenail loss

EMBO J 35:26862698 Kim DS, Challa S, Jones A, Kraus WL (2020) PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis

As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed