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These receptors are densely expressed in the hypothalamus, particularly the medial preoptic area (mPOA), a brain region critical for sexual behavior across multiple species

es capaz de aumentar la proliferacin de los linfocitos, lo que aumenta la magnitud de la respuesta, tambin aumentar la actividad de eliminacin de las clulas T citotxicas y las clulas NK, y la regulacin de la apoptosis, manteniendo as el control de la respuesta inmune