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Exploration of the efficacy and safety of different injection modalities of methylcobalamin in diabetic peripheral neuropathy

Mol Neurobiol (2021) 58(4):176981

3.5 System Configurations and Performance Considerations The configuration of the BAC system significantly impacts its performance, especially in terms of flow distribution and filtration efficiency

Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired