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doi: 10.1016/j.celrep.2022.110976 211 HaacMEAndersonMAEgglestonHMylesKMAdelmanZN

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therefore, the increased oxidative stress observed in FH-deficient cells could also contribute to Nrf2 activation

Consequently, PHGDH suppresses c-JUN poly(ADP-ribosyl)ation by both limiting NAD availability and directly binding to c-JUN, thereby blocking c-JUNdriven proliferation [115]