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The established maximum doses represent the upper limits studied in clinical trials, beyond which risk-benefit ratios become unfavorable

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Contraindications include active malignancy (GH/IGF-1 could theoretically promote tumor growth, though evidence is mixed), hypersensitivity to Sermorelin or GHRH, pituitary tumors or masses (stimulation could theoretically promote growth), and pregnancy/lactation (safety not established)

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