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Recognition of these electrophysiological alterations is crucial, as they may precede malignant ventricular arrhythmias and SCD

In biological systems, metal ions are strongly coordinated to aminothiol receptors including proteins and polypeptides

Despite this gap in knowledge, a plausible hypothesis could be formulated that either treatment with exogenous melatonin or interventions aimed at restoring endogenous melatonin secretion might offer potential in mitigating neurodegenerative processes induced by circadian disruption

Once a severe deficiency develops, anemia may or may not be present, or it may appear later