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But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

Huse A, Lindmark GM, Srensen PL, Heie , Weholt , Mroueh U, Wahlstrm M (1999) Categories and Quantities of mercury waste, and treatment capacity in the Nordic countries

Mol Cell 56(3):414424

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