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Hepatology 40 , 185194 (2004)

Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast

Ammonia may also disrupt sulfur amino acid metabolism by limiting transsulfuration-dependent conversion of methionine to cysteine, thereby reducing glutathione synthesis and weakening redox homeostasis in effector T cells ( 3 ) can diffuse across membranes and accumulate within acidic organelles, it may selectively increase lysosomal pH without necessarily altering the overall acidity of the tumor microenvironment (Voskoboinik et al., 2015