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Traditional Vitamin C circulating in the blood still requires active transport to enter target tissues like the brain, heart, and immune cells

L02 cells were transfected with GSTA1 or control plasmids for 36 h and further treated with or without bicyclol for 12 h

doi: 10.3389/fendo.2025.1610869 Received 13 April 2025 Accepted 18 July 2025 Published 06 August 2025 Volume 16 - 2025 Edited by Shafiya Imtiaz Rafiqi, University of Toledo, United States Reviewed by Marcos Edgar Herkenhoff, Santa Catarina State University, Brazil Haoxu Dong, Huazhong University of Science and Technology, China Victory Ashonibare, Heinrich Heine University of Dsseldorf, Germany Updates Copyright 2025 Jiang, Wang, Hua, Tang and Li

These findings support the use of microbiome-targeted interventions early in life or illness to potentially mitigate progression of severe psychiatric conditions