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Similarly, children and adolescents under chronic risperidone treatment showed a higher weight gain and, concurrently, changes in gut microbiota consisting in an altered ratio of Bacteroidetes: Firmicutes and an upregulation of metabolic pathways linked with weight gain, including alterations in butanoate, propanoate, fatty acid and tryptophan pathways [249]

Although known and proposed for more than a decade, phytoremediation of pharmaceuticals is scarcely applied and, until now, only limited data on the ecotoxicological effects of pharmaceutical substances and especially their effects on plants exist

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A study on rats with intracerebral hemorrhage (ICH) revealed that GHK pretreatment significantly improved neurological deficits, reduced brain water content, and inhibited neuronal apoptosis