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This region contains olfactory neurons that extend cilia into the mucus layer and project axons through the cribriform plate to synapse in the olfactory bulb, allowing drugs to bypass the BBB and reach the CNS directly via the olfactory and trigeminal nerve pathways (Crowe et al., 2018)

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Because the tubules in the renal cortex and outer medulla are vulnerable to oxidative injury (Figure 3A), glutathione production in these tissues is considered significant for kidney protection from IRI

Because biotinidase deficiency screening is performed by direct enzyme assay, results are not influenced by dietary protein intake, as is the case for phenylketonuria or other amino acidopathies