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Local administration is commonly used because its effects appear strongest close to the target tissue

These include blood thinners used to prevent Deep Vein Thrombosis (DVT), anti-inflammatories, and antibiotics

To rank them by the impact of genes involved in oligodendrogenesis, we introduced a knowledge-driven scoring procedure that we named OligoScore (here provided for the community as a resource

Compared to 108 control subjects without evidence of dementia, subjects with dementia of Alzheimer's type and confirmed Alzheimer's disease had higher blood levels of homocysteine and lower blood levels of folate and vitamin B 12